jmartin1208,
Have you set the circuit up without the I2C Extenders? It is best to verify that the circuit works as intended without the I2C Extenders first.
Assuming that the circuit works without the extenders, can provide more detail about how you have everything connected? How many series nodes and end nodes do you have? Where are your pullup resistors? How long is your cable run? What are the power sources for each element in the system?
Thanks,
Mark